Depression is more common—and more persistent—than many people realize. According to the CDC’s National Center for Health Statistics, the prevalence of depression in U.S. adolescents and adults has increased by 60% in the past decade. For some, symptoms improve with standard antidepressant medications. But for many others—especially those with treatment-resistant depression—traditional options like SSRIs (selective serotonin reuptake inhibitors) fall short.
For many people with treatment-resistant depression, standard SSRIs mean taking a pill every single day—sometimes for years—with no guarantee of meaningful change and a high chance remission if the meds are stopped. Spravato® offers a different approach. Administered in-office just once or twice a week over the course of several weeks, Spravato® can provide transformative results without the daily pill routine. This prescription nasal spray is given under medical supervision. The treatment works on a different brain pathway than traditional medications to treat depression, offering the potential for rapid symptom relief in people who haven’t found success with other antidepressants.
How Spravato is Different
The brand name, Spravato® is actually esketamine, developed and made available by Janssen Pharmaceuticals, Inc., which is a pharmaceutical company of Johnson & Johnson. It is a breakthrough medication that is administered via nasal spray under the care and supervision of a trained medical provider. It is innovative because it works by enhancing neuroplasticity which is different from other conventional medications for depression. Neuroplasticity is the brain’s ability to form new connections and strengthen existing ones. This process can help repair some of the damage caused by depression and potentially lead to rapid and lasting improvements in mood and overall mental health.
What makes Spravato® truly groundbreaking is how it works. Rather than relying on traditional serotonin-based pathways, it targets glutamate—the brain’s most abundant neurotransmitter—promoting neural connectivity much faster than older medications. Johns Hopkins psychiatrists highlight its rapid effects: for some people, relief may begin within hours rather than weeks.
Conventional medications approved to treat depression including SSRI medications as well as tear 2 SNRI medications are typically taken every single day, can take weeks or months to show an effect, and often need to be taken for years. For some people, depression doesn’t respond well to these typical therapies while others feel the depression improves yet they don’t like the side effects of these daily pills. Spravato® offers a different path.
Spravato®, approved by the FDA, is the first nasal spray specifically indicated for treatment-resistant depression. Patients have seen improvements in depressive symptoms as early as 24 hours after treatment, with sustained gains through four weeks. In clinical trials, remission rates were more than tripled for those receiving Spravato® compared to placebo at week 4.
Although other antidepressants can and are often taken along with Spravato® treatment some patients find that Spravato® allows them to reduce or even stop daily antidepressant pills—though individual results vary. Its appeal is not only in the science, but in the possibility of breaking free from a years-long medication routine.
Support Every Step of the Way
When it comes to insurance, coverage varies—but many insurers do support Spravato®. Depending on your plan, the medication may require prior authorization, and clinics usually handle the billing for both the drug and its administration through a combination of pharmacy and medical claims.
Navigating insurance coverage, scheduling treatments, and understanding what to expect can feel overwhelming when you’re already struggling with depression. That’s where Spravato with Me comes in. This patient support program provides personal guidance, helps with insurance approvals, assists in scheduling, and stays connected with you and your healthcare provider throughout the process.
Seven Springs Health & Wellness: Your Certified Spravato Provider
Seven Springs Health & Wellness is proud to be a REMS-certified clinic, which means we meet the rigorous safety and training standards required to provide Spravato® treatment. Here, you’ll receive care in a comfortable, monitored setting, with professionals who are experienced in both the medical and emotional needs of patients undergoing this therapy.
At Seven Springs Health and Wellness our partnership with Spravato with Me ensures that from your first consultation to your final dose, you’ll have a team dedicated to making the experience smooth, safe, and supportive.
A Turning Point in Treatment
For people living with treatment-resistant depression, Spravato® represents more than just another option—it’s a potential turning point. With a shorter treatment commitment, innovative science, and wraparound patient support, it offers new hope when other treatments haven’t worked.
If you’ve been searching for a path forward, we’re here to help you explore whether Spravato® could be the right step.
Spravato with Me, a personalized patient support program that helps you every step of the way. From insurance navigation to appointment scheduling and treatment guidance, they work with you and your healthcare provider to make the process smooth, informed, and stress-free.
For many, the combination of a shorter treatment commitment, innovative science, and hands-on support makes Spravato® not just another option—but a turning point.
Are you wondering if Spravato® is a treatment that you would like to consider? Contact a professional today for a free 15 minute phone consultation or an intake evaluation at Seven Springs Health and Wellness.
